Tet Proteins: Enzymes in DNA Methylation and Cellular Processes

Target Name: Methylcytosine dioxygenase (TET)

NCBI ID: P48689

Methylcytosine dioxygenase (TET)

Other Name(s): TET

Tet Proteins: Enzymes in DNA Methylation and Cellular Processes

Methylcytosine dioxygenase (TET) is an enzyme that plays a crucial role in the regulation of DNA methylation. Tet proteins are a family of enzymes that include four subtypes, including Tet1, Tet2, Tet3, and Tet4. Tet1 is the most abundant isoform and is involved in the conversion of 5-methylcytosine to 5-hydroxycytosine. The addition of a methyl group to cytosine residues is a critical step in the DNA methylation process, and Tet1 is the enzyme that initiates this process.

Tet2 is a critical enzyme for the repair of DNA damage caused by UV radiation and other stressors. Tet2 is involved in the conversion of 5-methylcytosine to 5-dihydroxycytosine, which is then converted to 5-dihydroxycytosine-5-monophosphate by Tet3 and further to 5-dihydroxycytosine by Tet4.

Tet3 is the enzyme that converts 5-dihydroxycytosine-5-monophosphate to 5-dihydroxycytosine. Tet3 is involved in the DNA damage repair process and is also involved in the regulation of cell growth and differentiation.

Tet4 is the least abundant isoform and is involved in the conversion of 5-dihydroxycytosine to 5-hydroxycytosine. Tet4 is also involved in the regulation of cell growth and differentiation.

Tet proteins have been implicated in a wide range of cellular processes, including DNA methylation, DNA repair, cell growth and differentiation, and cell cycle regulation. They are also involved in the regulation of gene expression and have been implicated in the development and progression of many diseases, including cancer.

In recent years, there has been a growing interest in Tet proteins as potential drug targets or biomarkers. The Tet gene has been targeted by several drugs, including Oncobase, which is a small molecule inhibitor of Tet1 that is currently in clinical trials for the treatment of various cancers.

Another drug that is being targeted by Tet research is Tet7, which is a small molecule inhibitor of Tet7 that is being developed for the treatment of various cancers.

Research has also shown that Tet proteins can be used as biomarkers for some diseases. For example, Tet1 has been used as a biomarker for cancer and Tet3 has been used as a biomarker for neurodegenerative diseases.

In addition to their potential use as drug targets or biomarkers, Tet proteins also have important roles in the regulation of DNA methylation. The addition of a methyl group to cytosine residues is a critical step in the DNA methylation process, and Tet enzymes are involved in this process at every step.

The regulation of DNA methylation is critical for the maintenance of cellular purity and the regulation of gene expression. Methylation of cytosine residues helps to ensure the stability of chromatin and the protection of genetic information. It also helps to prevent the accidental DNA double-strand break that can occur during DNA replication.

In addition to the regulation of DNA methylation, Tet enzymes are also involved in the regulation of cell cycle progression and the control of cell growth. They are involved in the G1 phase of the cell cycle and are thought to play a role in the regulation of G1 cell cycle progression to the S phase.

Tet enzymes are also involved in the regulation of cell differentiation and cell plasticity. They are thought to play a role in the regulation of stem cell proliferation and the maintenance of stem cell stem cell

Protein Name: Methylcytosine Dioxygenase (TET) (nonspecified Subtype)

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•   protein structure and compound binding;
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•   expression level;
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